Sepsis- The Dilemma Continues

Sepsis- The Dilemma Continues

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection [1]. Sepsis syndrome represents the body’s host response to infection. Classically, sepsis has been defined and classified as systemic inflammatory response syndrome (SIRS), sepsis and septic shock based on diagnostic criteria derived from the systemic response to inflammation (Figure 1)....

Quantifying latent TB infection: the dilemma continues.

Fragmented sleep has great effects on daily life, including sleepiness, impaired cognitive function, decreased mood, and elevated BP. 1 3 In an excellent study in a recent issue of CHEST (January 2010), Stamatakis and Punjabi 4 show that two nights of nonspecifi c sleep fragmentation in healthy volunteers led to decreased insulin sensitivity and glucose effectiveness despite normal sleep durati...

The prevention of prostate cancer--the dilemma continues.

Prostate cancer is the most common non-skin cancer in the United States, the second leading cause of death from cancer among U.S. men, and the seventh leading cause of death in the United States. The number of new cases of prostate cancer, now estimated at more than 220,000 per year, is expected to increase to more than 380,000 by 2025 because of the aging male population. The incidence of pros...

Frontline therapy for chronic lymphocytic leukemia: the dilemma continues.

To the Editor: I would like to congratulate Bosch and colleagues on a well-conducted clinical investigation confirming the activity of the FCM (fludarabine, cyclophosphamide, and mitoxantrone) program in previously untreated chronic lymphocytic leukemia (1). Bosch and colleagues reported that FCM provides an overall response rate of 90% with a complete response of 64%. In addition, using a high...

Gram-negative sepsis: what dilemma?